Cannabigerol (CBG) is one of several dozen cannabinoids in the cannabis plant. CBG interacts with several systems in the body, including the genes involved in cholesterol regulation, metabolic processes, dopamine, and the ATP to cAMP process (connected with our mood and immune systems, respectively) and genetic processes thought to be involved in cellular communication.
Interactions with these systems indicate CBG has the potential for many treatment and medicinal applications. CBG also helps reduce inflammation and chronic pain, alleviate nausea and vomiting, and patients using cannabis reported improved mood, including decreased depression and anxiety, after taking CBG-dominant cannabis preparations.
CBG is considered a “minor” cannabinoid. This means the cannabis plant contains smaller amounts of CBG than “major” cannabinoids like tetrahydrocannabinol (THC) or cannabidiol (CBD). CBG works as an appetite enhancer, a plant metabolite, a cannabinoid receptor agonist, an anti-inflammatory agent, an antibacterial agent, a neuroprotective agent, and an antioxidant.
What Is CBG in Weed?
Before the cannabis plant can produce CBG or other cannabinoids, acids and phosphates within the plant first produce cannabigerolic acid (CBGA) — a biosynthetic precursor to several cannabinoids. As the cannabis plant grows and develops, CBGA is derived from olivetolic acid.
Once CBGA is created, the plant synthesizes this acidic cannabinoid with enzymes to produce several non-acidic cannabinoids, including CBD, TCH, and of course, CBG. (You can read more about the difference between acidic and non-acidic cannabinoids here.)
The acidic form of CBG is something of a cannabinoid blueprint — the starting point from which many cannabinoids are produced. If we mapped out an “evolutionary line” of cannabinoids, CBGA would be considered a common ancestor for THC, CBD, CBG, and several other cannabinoids.
Cannabinoids interact with the body’s endocannabinoid system, a biological system that influences our central and peripheral nervous systems, motor functions, and memory.
What Is the Endocannabinoid System?
The endocannabinoid system (ECS) plays an important role in several vital functions in the body. The ECS assists in the development of the central nervous system, synaptic plasticity in the brain, and regulating the body’s response to external and internal damage or trauma.
The ECS network also consists of multiple cannabinoid receptors, including CB1 and CB2, endocannabinoids naturally produced by our body, and enzymes that help break down or metabolize cannabinoids after consumption.
As cannabinoids activate the CB1 and CB2 receptors in the endocannabinoid system, they interact with G-protein coupled receptors and other messenger proteins. Interactions with these proteins can help regulate or correct imbalances in various systems and responses, including immune and inflammation responses and cellular communication.
What Is CBG Used For?
Like many other cannabinoids, CBG has been found to interact with essential systems in the body, including genetic processes, immune system responses, and cellular communication.
While additional research is needed to fully uncover the treatment potential of this non-psychoactive cannabinoid, CBG is used for a variety of possible treatments, including:
- Possible treatment of glaucoma. This 2011 study found that synthetic CBG acts on novel cannabinoid receptors to reduce intraocular pressure (which can contribute to the development of glaucoma). Researchers noticed these effects were amplified when CBG was used in conjunction with another synthetic cannabinoid (WIN55,212-2), suggesting that cannabinoids may be more effective when combined — also known as the entourage effect.
- COVID-19 treatment. This 2022 study found that the acidic forms of CBG and CBD (CBGA and CBDA, respectively) prevented a SARS-CoV-2 pseudovirus from infecting human cells, and prevented entry of live SARS-CoV-2 into cells. CBGA and CBDA were also found to be effective in treating the Alpha and Beta variants of the COVID-19 virus.
- Treatment of motor function issues. This 2020 study found CBG (and CBD) influenced the expression of multiple genes involved in neurotransmitter processes, including glutamate, gamma-aminobutyric acid (GABA), and dopamine signaling. Influencing these processes could lead to revolutionary treatment methods for imbalances in our central nervous system, cellular communication, and more.
- Treatment of Parkinson’s disease. This 2018 study found that a synthetic CBG derivative was neuroprotective against inflammation-driven neuron damage in cells affected by Parkinson’s. The study also suggests CBG may activate the peroxisome proliferator-activated receptor-γ (PPARγ), a hormone linked to cellular differentiation and anti-inflammatory responses.
- Treatment of Multiple Sclerosis (MS). This 2012 study found synthetic CBG alleviated symptoms of Theiler's encephalomyelitis virus infection (a neuroinflammatory condition similar to MS). Results also showed decreased reactivity of microglia (scavenger cells) and modulated the expression of genes involved in MS pathophysiology. Researchers believe this hints at high (no pun intended) potential for the treatment of MS and other neuroinflammatory diseases.
- Treatment of inflammation. This 2022 study found CBG was an effective inhibitor of pro-inflammatory proteins. This 2000 study found CBG has analgesic and anti-inflammatory effects, indicating that there is scope for developing drugs which do not have the psychoactive properties of THC. Patients reported that cannabis was effective in relieving pain as well as symptoms of depression and anxiety.
Are There Any Side Effects Associated With CBG?
Like other cannabinoids, although there are several potential benefits, the use of CBG does not come without risk.
Because research studies on this cannabinoid are relatively new, not much is known about the possible side effects — especially compared to the known side effects of a cannabinoid like THC.
Although most side effects are reportedly mild and short-lived, possible side effects when using CBG include:
- Dry mouth
- Nausea or vomiting
- Decreased motor skills
- Panic or anxiety attacks (elderly people and women are at higher risk here)
Although unlikely, it is possible CBG may worsen or exacerbate existing symptoms of some chronic health issues. Always consult with your physician prior to use of cannabis products, including CBG.
CBG vs. Other Cannabinoids: Similarities & Differences
Some cannabinoids (most notably THC) contain psychoactive chemicals and produce feelings of euphoria or the “high” feeling when consumed.
Cannabis users often report benefits and positive effects like increased energy, feelings of relaxation, and a sense of calm or peace. Cannabis patients also report relief of chronic pain or inflammation, and a decrease in feelings of stress, anxiety, and depression.
Unlike THC and other psychoactive cannabinoid compounds, CBG is non-psychoactive and does not produce the “high” feeling when consumed. The cannabis plant contains several non-psychoactive cannabinoids, with CBD as the most well-known and common among them.
Although non-psychoactive cannabinoids won’t produce a “high” when consumed, CBG and CBD (and several other cannabinoids) share several potential benefits and properties, including anti-inflammatory properties, anti-nausea and anti-vomiting properties, and have shown promise in antipsychotic treatments.
In addition to cannabinoids like CBG, CBD, and THC, there are more than 100 known cannabinoids in the cannabis plant. Along with these cannabinoids, cannabis contains several other chemical compounds like flavonoids and terpenes, which can change the way our body responds and reacts when consuming cannabis products.
As the concentrations and combinations of these compounds vary, they can produce different results and effects on our body and mind. Some of these effects are amplified when cannabinoids work in tandem — also known as the entourage effect.
How To Use CBG
What Is CBG Good For?
CBG is a non-psychoactive cannabinoid found in the cannabis plant, with anti-inflammatory and antioxidant properties.
CBG is useful and shows promise in a number of possible treatment areas, including relief of chronic pain, anxiety, and stress.
What Is CBG Isolate?
Like all known cannabinoids, CBG can be isolated and extracted from cannabis. The end result is known as an isolate, and is typically 99% pure. This isolated CBG extract is often sold in oils, tinctures, or gummies.
While pure CBG has been found to have positive effects and properties, a lone cannabinoid is not as effective as several cannabinoids working together, because you miss out on the entourage effect.
CBG Cannabinoid and Full Spectrum Cannabis
Unlike an isolated cannabinoid, full-spectrum cannabis contains everything the cannabis plant has to offer. Rather than isolating and extracting a single cannabinoid, this process keeps all cannabinoids and other chemical compounds intact — including flavonoids and terpenes!
Because the plant is kept more “intact” than in other processing methods, we receive more of the plant’s benefits and positive effects.
Field Queen’s Raw Cannabis Powder
To maximize the positive effects of CBG and experience the entourage effect, we recommend raw cannabis powder from Field Queen. This raw cannabis powder contains everything the cannabis plant has to offer, with only the water removed. Field Queen’s raw cannabis powder contains CBG plus ten other cannabinoids, along with several flavonoids and terpenes — not to mention several vitamins, minerals, and antioxidants.
For the best CBG product available, visit Field Queen and experience the benefits of full-spectrum cannabis in a water-soluble capsule. Whether you add the powder to your morning coffee or smoothie for a quick energy boost, take a capsule after a workout to help with muscle relaxation and recovery, or simply want to take advantage of microdosing THC, see for yourself how Field Queen’s raw cannabis powder can help you.